產(chǎn)品目錄

規(guī)格	500 μg 1 mg 5 mg
CAS	1215507-88-2
別名	N/A
化學(xué)名	N/A
分子式	C10H12D3NO3·HCl
分子量	236.7
溶解度	DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 15 mg/ml
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Metanephrine-d3 is intended for use as an internal standard for the quantification of metanephrine by GC- or LC-MS. Metanephrine is an inactive metabolite of epinephrine .1 It is formed from epinephrine by catechol-O-methyl transferase (COMT).2 Urinary and plasma levels of metanephrine are increased in patients with pheochromocytoma, an adrenal medullary neuroendocrine tumor.3,4

1.Bilezikian, J.P., Dornfeld, A.M., and Gammon, D.E.Structure-binding-activity analysis of beta-adrenergic amines—I. Binding to the beta receptor and activation of adenylate cyclaseBiochem. Pharmacol.27(10)1445-1454(1978) 2.Kopin, I.J., Axelrod, J., and Gordon, E.The metabolic fate of H3-epinephrine and C14-metanephrine in the ratJ. Biol. Chem.236(7)2109-2136(1961) 3.Wolthers, B.G., Kema, I.P., Volmer, M., et al.Evaluation of urinary metanephrine and normetanephrine enzyme immunoassay (ELISA) kits by comparison with isotope dilution mass spectrometryClin. Chem.43(1)114-120(1997) 4.Goldstein, D.S., Eisenhofer, G., and Kopin, I.J.Sources and significance of plasma levels of catechols and their metabolites in humansJ. Pharm. Exp. Ther.305(3)800-811(2003)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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