產(chǎn)品目錄

規(guī)格	100mg 500mg
CAS	302-22-7
別名
化學(xué)名	(8R,9S,10R,13S,14S,17R)-17-acetyl-6-chloro-10,13-dimethyl-3-oxo-2,3,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl acetate
分子式	C23H29ClO4
分子量	404.93
溶解度	Chloroform: 50 mg/ml
儲存條件	Store at-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Chlormadinone is a derivative of progesterone with antiandrogen and antigonadotropic effects.

Progestogens can bind to nuclear receptor and then bind with DNA to form Progestogen Response Element, which will then activate the processes of transcription.

In vitro: When compared with other progesterone derivatives, chlormadinone showed a relatively strong positional effect. Chlormadinone was found to have high binding affinity to the progesterone receptor, resulting in strong progestogenic activity at the endometrium level. Chlormadinone could also prevent the LH surge in the same way as progesterone. In addition, chlormadinone could weakly bind to the glucocorticoid receptor, but not to either mineralocorticoid nor estrogen receptors. Chlormadinone at high doses competed effectively with androgens to block their effects and also downregulated the number of androgen receptors [1].

In vivo: Results from previous rat study showed that chlormadinone at low doses, similar to cyproterone acetate, was able to selectively impaire the epididymal function and maturation of spermatozoa without appreciably changing either testicular function or pituitary gonadotrophin secretion [2].

Clinical trial: In a previous open study of six healthy women with regular menstrual cycles, 5 mg chlormadinone was given twice a day. Results showed that the daily dose of 10 mg used alone could induce suppression of the LH surge and could provid an excellent method of contraception with both LH surge and endometrial atrophy. However, long-term studies were lacking to indicate that the use of the chlormadinone alone was not associated with a long-term decrease in estradiol secretion [1].

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實驗服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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