產(chǎn)品目錄

規(guī)格	50 mg 100 mg
CAS	126833-17-8
別名	N/A
化學(xué)名	N/A
分子式	C14H17Cl2NO2
分子量	302.2
溶解度	DMF: 5 mg/ml,DMSO: 3 mg/ml,Ethanol: slightly soluble
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Fenhexamid is a fungicide.1,2 It inhibits germ-tube elongation and mycelial growth of several strains of the plant pathogenic fungus B. cinerea (EC50s = 0.13-8.3 and 0.03-16.5 µM, respectively).1 Fenhexamid inhibits 3-ketoreductase (IC50 = 3 µM for the B. cinerea enzyme), is an estrogen receptor α (ERα) agonist (EC50 = 9 µM in a yeast reporter assay), and inhibits the androgenic effect of dihydrotestosterone in MDA-kb2 cells (IC20 = 2.02 µM).1,3,4 It increases the proliferation and migration of BG1 ovarian cancer cells when used at a concentration of 10 µM.5 In field studies, fenhexamid applied at 842 g AI/ha provides 27.3 and 13.9% disease control for lettuce drop caused by S. minor or S. sclerotiorum, respectively.2 Formulations containing fenhexamid have been used as fungicides in agriculture.

1.Debieu, D., Bach, J., Montesinos, E., et al.Role of sterol 3-ketoreductase sensitivity in susceptibility to the fungicide fenhexamid in Botrytis cinerea and other phytopathogenic fungiPest. Manag. Sci.69(5)642-651(2013) 2.Matheron, M.E., and Porchas, M.Activity of boscalid, fenhexamid, fluazinam, fludioxonil, and vinclozolin on growth of Sclerotinia minor and S. sclerotiorum and development of lettuce dropPlant Dis.88(6)665-668(2004) 3.Teng, Y., Manavalan, T.T., Hu, C., et al.Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cellsToxicol. Sci.131(1)71-83(2013) 4.Orton, F., Rosivatz, E., Scholze, M., et al.Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogensEnviron. Health Perspect.119(6)794-800(2011) 5.Go, R.-E., Kim, C.-W., and Choi, K.-C.Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer modelsToxicol. Appl. Pharmacol.289(1)48-57(2015)

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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