13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
在線訂購 免費訂購熱線：021-59541103 021-60443211
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詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 10g 25g |
| CAS | 604-59-1 |
| 別名 | 7,8-Benzoflavone,NSC 407011 |
| 化學名 | 2-phenyl-4H-naphtho[1,2-b]pyran-4-one |
| 分子式 | C19H12O2 |
| 分子量 | 272.3 |
| 溶解度 | ≥ 10mg/mL in DMSO |
| 儲存條件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
α-Naphthoflavone (α-NF), also known as 7,8-benzoflavone and 2-phenyl-benzo(h)chromen-4-one, is a synthetic flavone derivative. α-Naphthoflavone is a potent inhibitor of the enzyme aromatase, which implicated in converting testosterone to estrogen [1]. It can be prepared from 2-naphthol and cinnamaldehyde [2]. α-naphthoflavone functions as both an Ah receptor antagonist and an inhibitor of cytochrome P450 activity. α-naphthoflavone stimulated P450 3A4 by selectively binding and activating an otherwise inactive subpopulation of this P450 and promoting benzo[a]pyrene binding to the latter [3].
In vitro: α-NF inhibited microsomal rabbit CYP3A6 and human CYP3A4 irreversibly. α-NF and β-NF strongly inhibited CYP1A-mediated ethoxyresorufin O-deethylase (EROD) activity with the Ki value of 9.1 ± 0.8 and 7.6 ± 1.1 nM, respectively. α-NF at 0.5, 5, 50 and 500 μM inhibited liver microsome-catalyzed AFB1-DNA binding by 22, 58, 84 and 91%, respectively [4].
In vivo: α-NF inhibited CYP1A enzymes and caused both synergism and antagonism of retene toxicity to rainbow trout (Oncorhynchus mykiss) [5]. In male Sprague–Dawley rats, treatment with αNF had no significant effects on body mass after 5 days and caused only minor increases of liver, kidney, and heart CYP1A1 mRNA. In contrast, lung CYP1A1 mRNA was increased by αNF treatment to levels comparable to that seen with β-NF treatment [6]..
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原創作者：上海莼試生物技術有限公司
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普票匯款信息
賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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