產(chǎn)品目錄

規(guī)格	5 mg 10 mg 50 mg
CAS	1224-92-6
別名	N/A
化學(xué)名	N/A
分子式	C19H32O
分子量	276.5
溶解度	Chloroform: soluble
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

5α-Androstan-3β-ol is a steroidal androgen.1 It binds to the androgen receptor in a cell-free assay (IC50 = 1.7 μM) and activates the pregnane X receptor (PXR) in HepG2 cells in a reporter assay (EC50 = 0.8 μM).1,2 5α-Androstan-3β-ol also inhibits the androst-4-ene-3,17-dione hydroxylase activities of 16α- and 6β-hydroxylase but not 16β- or 7α-hydroxylase (IC50s = 70, 110, >150, and >150 μM, respectively).3 It decreases testis weight and sperm production in mice when administered at a dose of 30 mg/kg.4

1.Fang, H., Tong, W., Branham, W.S., et al.Study of 202 natural, synthetic, and environmental chemicals for binding to the androgen receptorChem. Res. Toxicol.16(10)1338-1358(2003) 2.Ekins, S., Chang, C., Mari, S., et al.Human pregnane X receptor antagonists and agonists define molecular requirements for different binding sitesMol. Pharmacol.72(3)592-603(2007) 3.Murray, M., and Mehta, I.Structure-activity relationships in the in vitro modulation of rat hepatic microsomal androst-4-ene-3,17-dione hydroxylase activities by derivatives of 5α- and 5β-androstaneJ. Steroid Biochem.35(3-4)465-471(1990) 4.Martinot, E., Baptissart, M., Véga, A., et al.Bile acid homeostasis controls CAR signaling pathways in mouse testis through FXRalphaSci. Rep.742182(2017)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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