產(chǎn)品目錄

規(guī)格	5mg 10mg 25mg
CAS	72122-62-4
別名	N/A
化學(xué)名	N/A
分子式	C41H55N7O9
分子量	789.92
溶解度	Soluble in DMSO
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

β-casomorphin, bovine (β-casomorphin-7) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay.

β-casomorphin(β-casomorphin-7) strongly stimulates mucin secretion in the rat jejunum through a nervous pathway and opioid receptor activation. In rat DHE cells, β-casomorphin(β-casomorphin-7) increases the expression of rat mucin (rMuc)2 and rMuc3 but not rMuc1, rMuc4, and rMuc5AC. In human HT29-MTX cells, β-casomorphin(β-casomorphin-7) also increases MUC5AC mRNA levels (219% after 24 h of stimulation) and the secretion of this mucin. β-casomorphin(β-casomorphin-7) may contribute significantly to mucin production via a direct effect on intestinal goblet cells and the activation of -opioid receptors[2].

Oral administration of β-casomorphin(β-casomorphin-7) for 30 days to rats with STZ-induced diabetes results in a significant increase in serum level of insulin, and a decrease in the level of glucagon. The administration of β-casomorphin(β-casomorphin-7) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats. β-casomorphin(β-casomorphin-7) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].

[1]. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9. [2]. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13. [3]. Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472.

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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