產(chǎn)品目錄

規(guī)格	500 μg 1 mg
CAS	470-40-6
別名	N/A
化學(xué)名	N/A
分子式	C15H24
分子量	204.4
溶解度	Chloroform: slightly soluble,Dichloromethane: slightly soluble
儲存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Thujopsene is a sesquiterpene that has been found in T. dolabrata and has diverse biological activities.1,2,3,4,5 It inhibits the Na+/K+-ATPase (IC50 = 25.9 μg/ml) and cytochrome P450 (CYP) isoform CYP2B6 (Ki = 0.8 μM).1,2 Thujopsene is active against Gram-positive and Gram-negative bacteria, including S. aureus, M. luteus, and S. typhimurium (MICs = 25-50 μg/ml).1 It inhibits antigen-induced β-hexosaminidase release from IgE-sensitized RBL-2H3 mast cells (IC50 = 25.1 μM) and is cytotoxic to A549 non-small cell lung cancer (NSCLC) cells with an LC50 value of 35.27 μg/ml.3,4 Thujopsene induces mortality in the mites D. farniae and T. putrescentiae (LC50s = 9.82 and 10.92 μg/cm2, respectively).5

1.Oh, I., Yang, W.-Y., Park, J., et al.In vitro Na+/K+-ATPase inhibitory activity and antimicrobial activity of sesquiterpenes isolated from Thujopsis dolabrataArch. Pharm. Res.34(12)2141-2147(2011) 2.Jeong, H.U., Kwon, S.S., Kong, T.Y., et al.Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomesJ. Toxicol. Environ. Health A.77(22-24)1522-1532(2014) 3.Kim, C.-H., Lee, T., Oh, I., et al.Mast cell stabilizing effect of (-)-Elema-1,3,11(13)-trien-12-ol and thujopsene from Thujopsis dolabrata is mediated by down-regulation of interleukin-4 secretion in antigen-induced RBL-2H3 cellsBiol. Pharm. Bull.36(3)339-345(2013) 4.Bordoloi, M., Saikia, S., Kolita, B., et al.Volatile inhibitors of phosphatidylinositol-3-kinase (PI3K) pathway: Anticancer potential of aroma compounds of plant essential oilsAnticancer Agents Med. Chem.18(1)87-109(2018) 5.Kim, J.-R., Perumalsamy, H., Kwon, M.J., et al.Toxicity of hiba oil constituents and spray formulations to American house dust mites and copra mitesPest Manag. Sci.71(5)737-743(2015)

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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