產(chǎn)品目錄

規(guī)格	500 μg 1 mg 5 mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C129H230N36O29S·XCF3COOH
分子量	2781.5
溶解度	DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 5 mg/ml
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1 It blocks the nuclear import of p105 in cells treated with activators of NF-κB signaling, including LPS and TNF-α.1 In this way, NF-κB inhibitor blocks gene expression that is regulated by NF-κB.2,3 This peptide is commonly used to evaluate the role of NF-κB signaling in cellular responses.4,5

1.Lin, Y.Z., Tao, S., Veach, R.A., et al.Inhibition of nuclear translocation of transcription factor NF-κB by a synthetic peptide containing a cell membrane-permeable motif and nuclear localization sequenceJ. Biol. Chem.270(24)14255-14258(1995) 2.Torgerson, T.R., Colosia, A.D., Donahue, J.P., et al.Regulation of NF-κB, AP-1, NFAT, and STAT1 nuclear import in T lymphocytes by noninvasive delivery of peptide carrying the nuclear localization sequence of NF-κB p50Journal of Immunology161(11)6084-6092(1998) 3.Kasibhatla, S., Genestier, L., and Green, D.R.Regulation of fas-ligand expression during activation-induced cell death in T lymphocytes via nuclear factor κBThe Journal of Biological Chemisty274(2)987-992(1999) 4.Methot, L., Hermann, R., Tang, Y., et al.Interaction and antagonistic roles of NF-κB and Hes6 in the regulation of cortical neurogenesisMolecular and Cellular Biology33(14)2797-2808(2013) 5.W?ster, P., Rosdahl, I., and ?linger, K.Cell fate regulated by nuclear factor-κB- and activator protein-1-dependent signalling in human melanocytes exposed to ultraviolet A and ultraviolet BBritish Journal of Dermatology171(6)1336-1346(2014)

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1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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