13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
在線訂購 免費訂購熱線：021-59541103 021-60443211
聯系人:高小姐
電話:021-59541103 021-60443211
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Q Q： 3004967995
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詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 10mg 50mg 100mg |
| CAS | 666179-74-4 |
| 別名 | N/A |
| 化學名 | N/A |
| 分子式 | C23H28ClFN4O2 |
| 分子量 | 446.95 |
| 溶解度 | Soluble in DMSO |
| 儲存條件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
Risperidone hydrochloride is a serotonin 5-HT2 receptor blocker and a potent dopamine D2 receptor antagonist, with Kis of 0.16, 1.4 nM for 5-HT2 and D2 receptor, respectively. 5-HT2 Receptor|0.16 nM (Ki)|D2 receptor|1.4 nM (Ki)
Risperidone is serotonin 5-HT2 receptor blocker as shown by displacement of radioligand binding (Ki=0.16 nM), activity on isolated tissues (EC50=0.5 nM). Risperidone is also a potent dopamine D2 receptor antagonist as indicated by displacement of radioligand binding (Ki=1.4 nM), activity in isolated striatal slices (IC50=0.89 nM)[1]. Risperidone increases the production of IL-10 and MDC as well as the proinflammatory cytokines, such as IL-6, IL-8, and TNF-α, but decreases the production of IP-10 and IL-12[2].
Long-Evans rats receive daily subcutaneous injections of vehicle or 1 of 2 doses of risperidone (1.0 and 3.0 mg/kg per day) from postnatal Days 14 to 42. Weight gain during development is slightly yet significantly reduced in risperidone-treated rats. In the first 2 experiments, early-life Risperidone administration is associated with increased locomotor activity at 1 week post administration through approximately 9 months of age, independent of changes in weight gain[2].
[1]. Chen ML, et al. Risperidone modulates the cytokine and chemokine release of dendritic cells and induces TNF-α-directed cellapoptosis in neutrophils. Int Immunopharmacol. 2012 Jan;12(1):197-204. [2]. Bardgett ME, et al. Adult rats treated with risperidone during development are hyperactive. Exp Clin Psychopharmacol. 2013 Jun;21(3):259-67.
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原創作者：上海莼試生物技術有限公司
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普票匯款信息
賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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