產(chǎn)品目錄

規(guī)格	5 mg 10 mg 25 mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C12H16N6O2S·2HCl [XH2O]
分子量	381.3
溶解度	DMSO: 15 mg/ml,Water: 5 mg/ml
儲存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Ro 04-6790 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT6 (Ki = 44.7 nM).1 It is selective for 5-HT6 receptors over a panel of 23 additional receptors at 10 µM. Ro 04-6790 inhibits 5-HT-induced cAMP production in HeLa cells expressing human 5-HT6 (pA2 = 6.75). In vivo, Ro 04-6790 (10 and 30 mg/kg) induces stretching and yawning behavior in rats. It reverses scopolamine-induced decreases in novel object discrimination in rats.2 Ro 04-6790 (3, 10, and 30 mg/kg) also attenuates cue-induced cocaine-seeking behavior in rats.3

1.Sleight, A.J., Boess, F.G., BÖs, M., et al.Characterization of Ro 04-6790 and Ro 63-0563: Potent and selective antagonists at human and rat 5-HT6 receptorsBr. J. Pharmacol.124(3)556-562(1998) 2.Woolley, M.L., Marsden, C.A., Sleight, A.J., et al.Reversal of a cholinergic-induced deficit in a rodent model of recognition memory by the selective 5-HT6 receptor antagonist, Ro 04-6790Psychopharmacology (Berl)170(4)358-367(2003)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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