產(chǎn)品目錄

規(guī)格	1mg 5mg 10mg 25mg
CAS	118506-26-6
別名	Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro
化學(xué)名	Myelin Basic Protein (87-99)
分子式	C74H114N20O17
分子量	1555.8
溶解度	≥ 77.8 mg/mL in DMSO, ≥ 15.97 mg/mL in EtOH with ultrasonic and warming, ≥ 50.7 mg/mL in H2O
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

The basic protein is a major structural protein of the central nervous system myelin in which it constitutes 30% of the total protein.(1)

T lymphocyte cell lines selected with whole MBP typically recognize only 1-3 immunodominant epitopes (Offner et al., 1987, 1988; Trotter et al., 1987: Bourdctte et al., 1988; McCarron and McFarlin, 1988) and these immunodominant MBP epitopes frequently are cncephalitogenic (Vandenbark et al., 1985b, 1989; Hashim et al., 1991). Thus, the identification of immunodominant MBP epitopes is likely to provide an in vitro method of identifying unrecognized enccphalitogenic epitopes of MBP. (2)

Although the cause of multiple sclerosis (MS) is not known, a T cell-mediated autoimmune process has been postulated. Myelin basic protein (MBP) is a potential target antigen because it induces experimental allergic encephalomyelitis (EAE) in susceptible animals. Encephalitogenic epitopes of MBP differ among susceptible strains and correlate with the MHC class II genotype. (3)

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1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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