產(chǎn)品目錄

規(guī)格	500 µg 1 mg 5 mg
CAS	N/A
別名	N/A
化學(xué)名	N/A
分子式	C15[13C]H18D3N5O2·HCl
分子量	355.9
溶解度	DMSO: soluble,Methanol: soluble,Water: soluble
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Alizapride-13C-d3 is intended for use as an internal standard for the quantification of alizapride by GC- or LC-MS. Alizapride is a dopamine D2 receptor antagonist (Ki = 66-340 nM in radioligand binding assays).1 It is selective for dopamine D2 over α1-, α2-, and β-adrenergic receptors (IC50s = >10 µM for all). It reduces decreases in gastrointestinal transit induced by dopamine , apomorphine, or bromocriptine in rats when administered at a dose of 5 mg/kg.2 Formulations containing alizapride have been used in the treatment of pre- and postoperative nausea.

1.Chivers, J.K., Gommeren, W., Leysen, J.E., et al.Comparison of the in-vitro receptor selectivity of substituted benzamide drugs for brain neurotransmitter receptorsJ. Pharm. Pharmacol.40(6)415-421(1988) 2.Dhasmana, K.M., VillalÓn, C.M., Zhu, Y.N., et al.The role of dopamine (D2), α and β-adrenoceptor receptors in the decrease in gastrointestinal transit induced by dopamine and dopamine-related drugs in the ratPharmacol. Res.27(4)335-347(1993)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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