產(chǎn)品目錄

規(guī)格	10 mM * 1 mL in DMSO 5mg 10mg 50mg 100mg
CAS	133059-99-1
別名	ICI-D 7288
化學(xué)名	(E)-N-ethyl-1,2-dimethyl-6-(methylimino)-N-phenyl-1,6-dihydropyrimidin-4-amine hydrochloride
分子式	C15H21ClN4
分子量	292.81
溶解度	50mg/mL in ethanol, 30mg/mL in DMSO or DMF
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

ZD 7288 is an inhibitor of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel [1].

The HCN channel is found in the sinoatrial node (SAN) and is permeable to both Na+ and K+. The HCN current exists in neurons under hyperpolarization of the cell membrane and plays an important role in neuropathic pain [1].

In CA1 pyramidal cells from Wistar rats, ZD 7288 inhibited T-type Ca2+ channel currents in a concentration-dependant way [2]. In neonatal rat facial motoneurones, ZD-7288 (0.1-10 μM) inhibited the hyperpolarisation-activated current with IC50 value of 0.2 μM in a time- and voltage-dependent way [3]. In CA1 pyramidal neurons, ZD 7288 (1-1000 μM) inhibited the hyperpolarization-activated current. However, ZD 7288 had no influence on long-term depression (LTD) of the CA3-CA1 synapse [4].

In rats with chronic visceral pain, ZD 7288 (50-100 nM) significantly inhibited abdominal withdrawal reflex (AWR) scores and electromyographic (EMG) responses. Also, ZD 7288 significantly increased pain thresholds. These results suggested that spinal HCN channels might play a critical role in chronic visceral pain [1].

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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