13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
聯系人:高小姐
電話:021-59541103 021-60443211
手機:13585831301
Q Q： 3004967995
Email:3004967995@qq.com
詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 10mM (in 1mL DMSO) 100mg |
| CAS | 88-58-4 |
| 別名 |
|
| 化學名 | 2,5-di-tert-butylbenzene-1,4-diol |
| 分子式 | C14H22O2 |
| 分子量 | 222.33 |
| 溶解度 | ≥ 8mg/mL in DMSO |
| 儲存條件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
BHQ is a selective inhibitor of endoplasmic reticulum Ca2+-ATPase.
Endoplasmic reticulum Ca2+-ATPase (SR Ca2+-ATPase) is a Ca2+-ATPase and transfers Ca2+ from the cytosol of the cell to the lumen of the sarcoplasmic reticulum (SR) during muscle relaxation.
BHQ is a selective SR Ca2+-ATPase inhibitor. In rat basophilic leukaemia cells, BHQ (10 μM) blocked inward rectifier potassium current and might cause depolarization of the cell and affect Ca2+ influx [1]. In aortic rings at rest or depolarised with 80 mM K+ in the presence of 1 mM nifedipine, BHQ induced a slow tonic contraction. At 20 mM K+, BHQ increased Ca2+-induced contraction. However, BHQ inhibited Ca2+-induced contraction at 40, 80 and 128 mM K+ [2]. In smooth muscle cells from the rat tail artery, BHQ reduced L-type Ca2+ current (ICa(L)) with IC50 value of 66.7 μM in a concentration- and voltage-dependent way. BHQ increased superoxide anion formation, which was markedly inhibited by superoxide dismutase (SOD). These results suggested that BHQ inhibited ICa(L) by the generation of superoxide anion [3]. In Madin Darby canine kidney (MDCK) cells, BHQ increased [Ca2+]i with EC50 value of 40 μM in a dose-dependent way, which was contributed by depleting the endoplasmic reticulum Ca2+ store followed by capacitative Ca2+ entry [4].
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原創作者：上海莼試生物技術有限公司
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賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
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