13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
聯系人:高小姐
電話:021-59541103 021-60443211
手機:13585831301
Q Q： 3004967995
Email:3004967995@qq.com
詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 10mg 50mg |
| CAS | 945828-50-2 |
| 別名 |
|
| 化學名 | (E)-ethyl hydrogen (2-amino-4-((2,4,6-trimethylbenzyl)amino)phenyl)carbonimidate |
| 分子式 | C19H25N3O2 |
| 分子量 | 327.42 |
| 溶解度 | <32.74mg/ml in DMSO |
| 儲存條件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
AA 29504, {2-amino-4-(2, 4, 6-trimethylbenzylamino)-phenyl}-carbamic acid ethyl ester is a positive modulator of extrasynaptic GABAA receptors. AA 29504 is also an analogue of the KCNQ channel opener retigabine with a 3-4 fold lower potency than retigabine. The EC50 of AA 29504 at KCNQ channels is between 9.6 and 13.5 μM [2]. AA 29504 at 1 µM had no agonist activity when tested at α1β3γ2s or α4β3δ GABAA receptors expressed in Xenopus oocytes, but left-shifted the EC50 of GABA and gaboxadol (THIP) at both receptors. The maximum GABA response was unchanged at α1β3γ2s receptors by AA 29504 (1 µM), but increased 3-fold at α4β3δ receptors [1].
GABA transiently activates synaptic GABAA receptors, leading to the classical inhibitory post-synaptic currents (phasic inhibition) [2]. KCNQ (also termed Kv7) channels are voltage-dependent potassium channels composed of homo- and heteromeric complexes of five different KCNQ subunits (KCNQ1–5, or called Kv7.1–Kv7.5) [3].
In Xenopus oocytes, AA 29504 at concentrations below 3 µM exhibited no intrinsic activity, whereas at 3 µM and above AA 29504 could induce a small response, which could not be blocked by bicuculline. Treatment with AA 29504 at a concentration of 1 µM showed no intrinsic activity at GABAA receptors and KCNQ channels, but left-shifted the concentration-response curve of GABA without affecting the maximum response to GABA [1].
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原創作者：上海莼試生物技術有限公司
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普票匯款信息
賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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