產(chǎn)品目錄

規(guī)格	10mg 50mg
CAS	389888-02-2
別名
化學名	(S)-2-amino-3-(2,4-dioxo-2,3,4,5,6,7-hexahydro-1H-cyclopenta[d]pyrimidin-1-yl)propanoic acid
分子式	C10H13N3O4
分子量	239.23
溶解度	<11.96mg/ml in H2O
儲存條件	Desiccate at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

(S)-CPW 399 is a potent and selective agonist of AMPA receptor with Ki value of 747 nM [1].

The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) is an ionotropic transmembrane receptor for glutamate and mediates fast synaptic transmission in the central nervous system. AMPA receptors are oligomeric assemblies of four protein subunits, GluR1-4.

(S)-CPW 399 is a potent and selective AMPA receptor agonist. (S)-CPW 399 exhibited affinity with Ki values of 109, 218, 2137 and 1756 nM for GluR1, GluR2, GluR3 and GluR4 receptors, respectively [1]. In mouse cerebellar granule cells, (S)-CPW 399 induced neuronal cell death in a concentration- and time-dependent way with EC50 value of 70 μM and increased intracellular free-calcium levels ([Ca2+]i ) in a concentration-dependent way with EC50 value of 5 μM [2]. In rat cerebellar granule cells, CPW-399 increased the expression of GABAA receptor δ subunit, which relied on NMDA receptor activation [3]. In Sf9 cells expressing iGluR5, (S)-CPW 399 exhibited affinity for iGluR5 with Ki value of 44 nM. In Xenopus læVis Oocytes, (S)-CPW 399 exhibited agonist activity with EC50 values of 24.9, 13.9, 224 and 34.3 μM for iGluR1, iGluR2, iGluR3 and iGluR4 receptors, respectively [4].

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實驗服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術有限公司

在線咨詢

留言注意事項：

1.遵守中華人民共和國有關法律、法規(guī)，尊重網(wǎng)上道德，承擔一切因您的行為而直接或間接引起的法律責任。

2.請您真實的反映產(chǎn)品的情況,不要捏造、誣蔑、造謠。如對產(chǎn)品有任何疑問,也可以留言咨詢。

3.未經(jīng)本站同意，任何人不得利用本留言簿發(fā)布個人或團體的具有廣告性質(zhì)的信息或類似言論。

您感興趣的產(chǎn)品*
您的單位*
聯(lián)系人*
聯(lián)系電話*
詳細地址*
常用郵箱*
請輸入您對我們的意見或建議*
驗證碼*