13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
聯系人:高小姐
電話:021-59541103 021-60443211
手機:13585831301
Q Q： 3004967995
Email:3004967995@qq.com
詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 100 mg |
| CAS | 58-89-9 |
| 別名 | N/A |
| 化學名 | N/A |
| 分子式 | C6H6Cl6 |
| 分子量 | 290.8 |
| 溶解度 | Chloroform: 50 mg/ml,Ethanol: >1 mg/ml,Methanol: >1 mg/ml,Water: 8.35 mg/ml |
| 儲存條件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
γ-Lindane is an organochloro insecticide that is an antagonist of GABAA receptors.1 It inhibits GABA-stimulated chloride uptake by membrane vesicles isolated from rat cerebral cortex (IC50 = 68 μM). It binds selectively to insect GABAA receptors over mammalian GABAA receptors in membrane preparations (IC50s = 1, 12, 505, 833, and 150-1, 675 nM for fruit fly, house fly, human, mouse, and rat, respectively).2,3 It binds to a human recombinant β3 homooligomer with similar selectivity as α1β3γ2-containing receptors, indicating that the binding site for γ-lindane on GABAA receptors is located on the β3 subunit (IC50s = 0.90, 21, and 306 nM for β3, α1β3γ2, and the native receptor, respectively).4 γ-Lindane blocks GABA- and glutamate-induced current responses in American cockroach neurons (IC50s = 1.74 and 148 nM, respectively).5 It is toxic to mice and adult house flies (LD50s = 40 and 5.5 mg/kg, respectively) and also kills head lice in vitro and inhibits hatching.4,6
1.Obata, T., Yamamura, H.I., Malatynska, E., et al.Modulation of -aminobutyric acid-stimulated chloride influx by bicycloorthocarboxylates, bicyclophosphorus esters, polychlorocycloalkanes and other cage convulsantsJ. Pharmacol. Exp. Ther.244(3)802-806(1988) 2.Hainzl, D., Cole, L.M., and Casida, J.E.Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproductChem. Res. Toxicol.11(12)1529-1535(1998) 3.Llorens, J., SuÑol, C., Tussel, J.M., et al.Lindane inhibition of [35S]TBPS binding to the GABAA receptor in rat brainNeurotoxicol. Teratol.12(6)607-610(1990) 4.Ratra, G.S., Kamita, S.G., and Casida, J.E.Role of human GABAA receptor β3 subunit in insecticide toxicityToxicol. Appl. Pharmacol.172(3)233-240(2001) 5.Ihara, M., Ishida, C., Okuda, H., et al.Differential blocking actions of 4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) and -hexachlorocyclohexane (-HCH) on -aminobutyric acid- and glutamate-induced responses of American cockroach neuronsInvert. Neurosci.5(3-4)157-164(2005) 6.Meinking, T.L., Taplin, D., Kalter, D.C., et al.Comparative efficacy of treatments for pediculosis capitis infestationsArch. Dermatol.122(3)267-271(1986)
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原創作者：上海莼試生物技術有限公司
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賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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