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Tazarotene

  • 產品貨號：CS-01Y73953
  • 產品價格：電議
  • 產品產地：進口、國產
  • 包裝類型:10mM (in 1mL DMSO) 5mg 25mg 100mg
  • 采購熱度：508
  • 庫存：100
  • CAS號：118292-40-3
  • 方法：
  • 含量：99.95%
  • 品牌名稱:莼試
  • 分子式：C21H21NO2S
  • 分子量：351.46

簡介內容：質量保證、價格優惠

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標簽:Tazarotene 

產品目錄

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商品詳情購物流程代測服務付款方式常見問題

化學性質：                                                                                                             

規格

10mM (in 1mL DMSO) 5mg 25mg 100mg

CAS

118292-40-3

別名

N/A

化學名

ethyl 6-[2-(4,4-dimethyl-2,3-dihydrothiochromen-6-yl)ethynyl]pyridine-3-carboxylate

分子式

C21H21NO2S

分子量

351.46

溶解度

≥ 14.85mg/mL in DMSO, ≥ 11.1 mg/mL in EtOH with ultrasonic

儲存條件

Store at 2-8°C

General tips

For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

產品描述：                                                                                                            

Tazarotene, one of the acetylenic class of retinoids, is the 3rd-generation prescription topical retinoid.  It is approved for treating psoriasis, acne, and photo damaged skin  [1].

Tazarotene act as a retinoid prodrug and it is converted to free acid form by rapid deesterification when used in man and animals. Tazarotenic acid shows selectivity for (RAR)-β, and (RAR)-γ though it could bind to all three classes of the retinoic acid receptor (RAR) family, and this may modify gene expression.

Tazarotene mediates these effects by regulating gene transcription. Five nonsmall cell lung carcinoma (NSCLC) cell lines and the constitutive and all-trans retinoic acid (ATRA)-inducible expression of tazarotene-induced gene3 mRNA of the five head and neck squamous cell carcinoma (HNSCC) were examined to determine whether it is associated with their responsiveness to ATRA. Consequently, ATRA induced tazarotene-induced gene3 mRNA from 6 to 12h in most of the responsive cells. Depending on the cell line, the concentration of ATRA required for induction of tazarotene-induced gene3 was ranged from 1 to 500 nm [2].

67 patients aging from 13 to 30 with facial acne attended a study to evaluate the safety and efficacy of topical tazarotene 0.1% cream in the treatment of facial acne. Patients were instructed to apply topical tazarotene cream (0.1%) as a thin film over the affected part in the evening once a day for 12 weeks. And follow-ups were done at 2nd, 4th, 8th and 12th week. As a result, 53% of the patients got remission, 9% had good response, 34% had poor response and 4% of the patients by 12 weeks of treatment was no response. Topical tazarotene cream (0.1%) is an effective and safe treatment method for the face affected by acne vulgaris [3].

特別提醒：                                                                                                              

1. 本產品僅供科研使用。請勿用于醫藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區。

2. 為了您的安全和健康，請穿好實驗服并佩戴一次性手套和口罩操作。

原創作者：上海莼試生物技術有限公司

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