13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
聯系人:高小姐
電話:021-59541103 021-60443211
手機:13585831301
Q Q： 3004967995
Email:3004967995@qq.com
詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 10mM (in 1mL DMSO) 20mg |
| CAS | 6902-77-8 |
| 別名 |
|
| 化學名 | methyl (1R,4aS,7aS)-1-hydroxy-7-(hydroxymethyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylate |
| 分子式 | C11H14O5 |
| 分子量 | 226.23 |
| 溶解度 | ≥ 9.8 mg/mL in DMSO, ≥ 101.6 mg/mL in EtOH, ≥ 5.97 mg/mL in H2O |
| 儲存條件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
IC50: 88.41 M for hepatitis C virus
Genipin, a compound derived from Gardenia jasminoides Ellis fruits, has been used over the years in traditional Chinese medicine to treat symptoms of type 2 diabetes.
In vitro: Previous study indicated genipin could stimulate the glucose uptake in a time- and dose-dependent manner. Genipin promoted glucose transporter 4 translocation to the cell surface in myotubes. Moreover, in the cytoplasm in C2C12 myotubes, genipin increased ATP levels, then shut down KATP channels, and finally increased the calcium concentration. In addition, genipin-stimulated glucose uptake could be blocked by wortmannin and calcium chelator EGTA, two PI3-K inhibitors. Furthermore, in C2C12 myotubes, genipin increased the level of reactive oxygen species and ATP [1].
In vivo: In rat liver after infusion of genipin, the biliary secretion of Mrp2 substrates, the subcellular localization, and mRNA level of Mrp2 were assessed. Results showed that in the CMVs, genipin treatment increased the protein mass of Mrp2 but not the mRNA level. Such effects were not observed in Mrp2-deficient rats. In addition, a marked increase in Mrp2 density in the canalicular membrane and microvilli was observed in the genipin-treated liver tissue sections [2].
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原創作者：上海莼試生物技術有限公司
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普票匯款信息
賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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