產(chǎn)品目錄

規(guī)格	500 µg 1 mg 5 mg
CAS	1330236-06-0
別名	N/A
化學(xué)名	N/A
分子式	C25H26ClD6N5O2·HCl
分子量	512.5
溶解度	DMSO: soluble,Methanol: soluble
儲存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Nefazodone-d6 (hydrochloride) is intended for use as an internal standard for the quantification of nefazodone by GC- or LC-MS. Nefazodone is a serotonin (5-HT), norepinephrine, and dopamine reuptake inhibitor (SNDRI; Kis = 137, 570, 2,380 nM, respectively, in rat brain synaptosomes).1 It is also an antagonist of 5-HT2A, 5-HT1A, and histamine H1 receptors, as well as α1- and α2-adrenergic receptors (α2-ARs; Kis = 7.1, 52, 30, 5.5, and 84 nM, respectively).2 Nefazodone (100 mg/kg) reduces immobility time in the tail suspension test in gerbils.3 However, it is toxic to isolated human hepatocytes in a cultured sandwich hepatocyte preparation when used at a concentration of 30 µM.4 Formulations containing nefazodone have previously been used in the treatment of depression.

1.Carlier, P.R., Lo, M.M.-C., Lo, P.C.-K., et al.Synthesis of a potent wide-spectrum serotonin-, norepinephrine-, dopamine-reuptake inhibitor (SNDRI) and a species-selective dopamine-reuptake inhibitor based on the gamma-amino alcohol functional groupBioorg. Med. Chem. Lett.8(5)487-492(1998) 2.Owens, M.J., Neal, W., Plott, S.J., et al.Neurotransmitter receptor and transporter binding profile of antidepressants and their metabolitesJ. Pharmacol. Exp. Ther.283(3)1305-1322(1997) 3.Varty, G.B., Cohen-Williams, M.E., and Hunter, J.C.The antidepressant-like effects of neurokinin NK1 receptor antagonists in a gerbil tail suspension testBehav. Pharmacol.14(1)87-95(2003) 4.Kostrubsky, S.E., Strom, S.C., Kalgutkar, A.S., et al.Inhibition of hepatobiliary transport as a predictive method for clinical hepatotoxicity of nefazodoneToxicol. Sci.90(2)451-459(2006)

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實(shí)驗服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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