產(chǎn)品目錄

規(guī)格	50mg 100mg 500mg
CAS	30034-03-8
別名	Cephamandole
化學名	(6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, monosodium salt
分子式	C18H17N6O5S2 Na
分子量	484.5
溶解度	≤30mg/ml in DMSO;30mg/ml in dimethyl formamide
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

MIC: 0.25-2 mg/L for different E. coli strains

Cefamandole is a cephalosporin antibiotic.

The cephalosporins are a class of β-lactam antibiotics originally derived from the fungus Acremonium, which was previously known as "Cephalosporium".

In vitro: The in-vitro effect of cefamandole was tested against 645 strains of bacteria isolated from clinical sources. Against gram-positive organisms cefamandole showed great potency, being three- to four-fold more active than cephalexin or cefoxitin. None of the Pseudomonas aeruginosa strains were susceptible to 100 μg of cefamandole per ml [1].

In vivo: The testicular toxicity of cefamandole was evaluated in neonatal rats. Results showed that cefamandole caused delayed maturity of the germinal epithelium of neonatal rats. In rats given daily subcutaneous injections during this period, the most mature germinal cells were acrosome phase spermatids [2].

Clinical trial: A randomized, single-blind comparison of parenteral cefamandole and ampicillin was conducted in adult patients with pneumonia or purulent tracheobronchitis. Results showed that cefamandole was as effective and safe as ampicillin. Of the 14 patients treated with cefamandole, 13 were considered cured, as were 12 of the 13 treated with ampicillin [3].

特別提醒：

1. 本產(chǎn)品僅供科研使用。請勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區(qū)。

2. 為了您的安全和健康，請穿好實驗服并佩戴一次性手套和口罩操作。

原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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