產(chǎn)品目錄

規(guī)格	10mM*1mLinDMSO 2mg 5mg 10mg 25mg 50mg 100mg
CAS	1338780-86-1
別名	N/A
化學(xué)名	N/A
分子式	C17H19F3N2O
分子量	324.34
溶解度	DMSO : 6 mg/mL (18.50 mM)
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

AU1235 is an adamantyl urea inhibitor of Mycobacterium tuberculosis.

AU1235 has a minimum inhibitory concentration (MIC) of 0.1 μg/mL (0.3 μM) (minimum bactericidal concentration of 0.1 μg/mL. AU1235 is similarly active against MDR clinical isolates of M. tb displaying resistance to isoniazid, rifampicin, and pyrazinamide in addition to streptomycin, fluoroquinolones and/or ethambutol. AU1235 also inhibits Mycobacterium smegmatis and Mycobacterium fortuitum (MICs=3.2 to 6.4 μg/mL). AU1235 (10 times MIC) does not increase the killing effect within the first 7 days indicating that the killing is time-dependent rather than concentration-dependent. In an anaerobic model involving non-replicating M. tb H37Rv bacilli, AU1235 at 10 μg/mL shows no detectable activity suggesting that it acts on a biosynthetic pathway required for active bacterial multiplication. AU1235 does not inhibit the biosynthesis of mycolic acids per se but specifically their ability to be transferred onto their cell wall and outer membrane acceptors, possibly as a result of altered TMM translocation across the plasma

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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