產(chǎn)品目錄

規(guī)格	10 mg 25 mg 50 mg 100 mg
CAS	73346-79-9
別名	N/A
化學(xué)名	N/A
分子式	C26H43O9·Li
分子量	506.6
溶解度	Ethanol: 30 mg/ml,PBS (pH 7.2): 1 mg/ml
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Pseudomonic acid is an antibiotic and bacterial metabolite that has been found in P. fluorescens.1 It is bacteriostatic against S. aureus (MIC = 0.05 μg/ml) and active against skin wound clinical isolates of methicillin-resistant S. aureus (MRSA; MICs = 1-4 μg/ml).2,3 Pseudomonic acid inhibits MRSA and P. aeruginosa biofilm formation in vitro.4 It inhibits bacterial cell wall isoleucyl-tRNA synthetase, slowing bacterial growth.2,4 Topical administration of pseudomonic acid (2% v/v) reduces the number of wound colony forming units (CFUs) in a mouse model of MRSA skin infection.3

1.Fuller, A.T., Mellows, G., Woolford, M., et al.Psuedomonic acid: An antibiotic produced by Pseudomonas fluorescensNature234(5329)416-417(1971) 2.Hughes, J., and Mellows, G.On the mode of action of pseudomonic acid: Inhibition of protein synthesis in Staphylococcus aureusJ. Antibiot. (Tokyo)31(4)330-335(1978) 3.Mohammad, H., Cushman, M., and Seleem, M.N.Antibacterial evaluation of synthetic thiazole compounds in vitro and in vivo in a methicillin-resistant Staphylococcus aureus (MRSA) skin infection mouse modelPLoS One10(11)e0142321(2015) 4.Khoshnood, S., Heidary, M., Asadi, A., et al.A review on mechanism of action, resistance, synergism, and clinical implications of mupirocin against Staphylococcus aureusBiomed. Pharmacother.1091809-1818(2019)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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