產(chǎn)品目錄

規(guī)格	5mg 10mg 50mg
CAS	69839-83-4
別名
化學(xué)名	N-3,4-tridhydroxy-benzamide
分子式	C7H7NO4
分子量	169.1
溶解度	≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Didox is a synthetic antioxidant.

Polyhydroxylated aromatic compounds, both natural and synthetic, are important biological antioxidants.

In vitro: In a previous study, the brain tissue from patients with HIV encephalitis was immunostained for lipid peroxidation. The presence of oxidized proteins in the CSF and CSF-induced progressive decrease in mitochondrial activity correlated with the severity of cognitive impairment. Didox together with L-deprenyl, imidate, diosgenin, and ebselen could block the CSF-induced toxicity. No effect of trimidox, ruthenium red, or Quercetin was seen [1]. Another study found that the exposure of didox prior or post to radiation in both PC-3/vector and PC-3/Bcl-2 transfectants led to an increase in radiation enhancement ratios. A significant reduction in G(2)M phase was observed in cells exposed to didox post IR when compared to cells exposed to IR alone. In addition, the exposure to didox after radiation in PC-3/vector significantly abrogated radiation-induced Bcl-2 upregulation [2].

In vivo: In syngeneic, therapy-resistant AML models, single agent didox treatment led to a significant reduction in leukemia burden and a survival benefit. Didox was well tolerated and didox exposure at levels that impaired leukemia growth did not inhibit normal HSC engraftment [3].

Clinical trial: So far, no clinical study has been conducted.

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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