13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
在線訂購(gòu) 免費(fèi)訂購(gòu)熱線：021-59541103 021-60443211
標(biāo)簽:CDK9 inhibitor
聯(lián)系人:高小姐
電話:021-59541103 021-60443211
手機(jī):13585831301
Q Q： 3004967995
Email:3004967995@qq.com
詳細(xì)地址：上海嘉定區(qū)嘉羅公路1661
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化學(xué)性質(zhì)：
| 規(guī)格 | 5mg 10mg 50mg |
| CAS | 1415559-43-1 |
| 別名 |
|
| 化學(xué)名 | N-[5-[[6-[3-(1,3-dioxoisoindol-2-yl)phenyl]pyrimidin-4-yl]amino]-2-methylphenyl]methanesulfonamide |
| 分子式 | C26H21N5O4S |
| 分子量 | 499.54 |
| 溶解度 | Soluble in DMSO |
| 儲(chǔ)存條件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產(chǎn)品描述：
CDK9 inhibitor is a small-molecule selective inhibitor of CDK9 (cyclin dependent kinase 9) with IC50 value of 39 nM [1].
CDKs are a group of serine/threonine kinases and are widely spread in all known eukaryotes. CDKs are activated through binding to cyclins and forming heterodimers. In the dimer, CDK acts as a catalytic subunit and phosphorylates the down-stream proteins such as nuclear lamina protein, nucleolin and histone H1. Through this way, CDKs take participate in the cell cycle regulation. CDK9 is a special member of the CDK family. It can affect the elongation phase of transcription through phosphorylating RNA polymerase II. The partner of it is positive elongation factor b (P-TEFb). It is reported that CDK9 is necessary for the infection of many kinds of viruses such as HIV-1 and HSV1 [1].
CDK9 inhibitor is a 4-aminophenyl derivative based on the (6-phenyl-pyrimidin-4-yl)-phenylamine structure. It showed elevated selectivity against CDK9 than the previous found inhibitors. The IC50 values of CDK9 inhibitor for CDK1/CycB, CDK2/CycE, CDK3/CycE, CDK4/CycD1, CDK5/p35, CDK6/CycD1 and CDK7/CycH are all higher than 1 μM. CDK9 inhibitor has no cytotoxicity. The treatment of CDK9 inhibitor at concentrations of 1 μM and 2 μM resulted in the cell viabilities of 101% and 115%, respectively. It also showed no significant toxicity in H9 cells. In the p24 assay, CDK9 inhibitor exerted its potency in inhibiting HIV-1 propagation with about 10% reduction of p24 production [1].
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原創(chuàng)作者：上海莼試生物技術(shù)有限公司
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普票匯款信息
賬 戶 名：上海生物
開(kāi) 戶 行：中國(guó)銀行山東省分行營(yíng)業(yè)部
賬 號(hào)：2169 2341 6278
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