產(chǎn)品目錄

規(guī)格	500μg 1mg 5mg
CAS	1174683-49-8
別名	N/A
化學(xué)名	N/A
分子式	C22H18BrD6FN4O2
分子量	481.4
溶解度	DMSO: soluble,Methanol: soluble,THF: soluble
儲(chǔ)存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Vandetanib-d6 is intended for use as an internal standard for the quantification of Vandetanib by GC- or LC-MS. Vandetanib is a broad spectrum, orally available kinase inhibitor that targets primarily tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR), with IC50 values in the nanomolar range.1,2 It also potently blocks non-receptor tyrosine kinases, including ABL, RET, and SRC, as well as several serine/threonine kinases.3,4 Primarily because of its effects on receptor tyrosine kinases like VEGFR and EGFR, vandetanib inhibits angiogenesis, cell growth, and metastasis and is effective against certain forms of cancer.4,5

|1. Kiselyov, A.S., Piatnitski, E., Milligan, D., et al. 1H-1,2,4-Triazol-3-yl-anilines: Novel potent inhibitors of vascular endothelial growth factor receptors 1 and 2. Chem.Biol.Drug Des. 69(5), 331-337 (2007).|2. Hennequin, L.F., Stokes, E.S.E., Thomas, A.P., et al. Novel 4-anilinoquinazolines with C-7 basic side chains: Design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. Journal of Medicinal Chemistry 45(6), 1300-1312 (2002).|3. Davis, M.I., Hunt, J.P., Herrgard, S., et al. Comprehensive analysis of kinase inhibitor selectivity. Nat.Biotechnol. 29(11), 1046-1051 (2011).|4. Morabito, A., Piccirillo, M.C., Falasconi, F., et al. Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions. Oncologist 14(4), 378-390 (2009).|5. Ton, G.N., Banaszynski, M.E., and Kolesar, J.M. Vandetanib: A novel targeted therapy for the treatment of metastatic or locally advanced medullary thyroid cancer. Am. J. Health Syst. Pharm. 70(10), 849-855 (2013).

特別提醒：

1. 本產(chǎn)品僅供科研使用。請(qǐng)勿用于醫(yī)藥、臨床診斷或治療，食品及化妝品等用途。請(qǐng)勿存放于普通住宅區(qū)。

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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