13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
聯系人:高小姐
電話:021-59541103 021-60443211
手機:13585831301
Q Q： 3004967995
Email:3004967995@qq.com
詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 10 mg 25 mg 50 mg |
| CAS | 205687-01-0 |
| 別名 | N/A |
| 化學名 | N/A |
| 分子式 | C18H26O4 |
| 分子量 | 306.4 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml |
| 儲存條件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
Capsiate is a non-pungent analog of capsaicin that has been found in C. annuum and has diverse biological activities.1,2,3,4 It inhibits Src in, as well as VEGF-induced proliferation of and tube formation by, human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 25 μM.1 Capsiate activates transient receptor potential vanilloid 1 (TRPV1) in HEK293 cells expressing the human channel (EC50 = 290 nM) and induces licking and biting behaviors, markers of nociception, in mice.2 Topical application of capsiate reduces antigen-induced increases in ear thickness in a mouse model of passive cutaneous anaphylaxis and decreases epidermal thickness and eosinophil and mast cell infiltration in a mouse model of atopic dermatitis.3 Capsiate (10 mg/kg) decreases body weight gain and perirenal fat weight, as well as increases oxygen consumption, fat oxidation, and carbohydrate oxidation, in a mouse model of ad libitum feeding-induced weight gain.4
1.Pyun, B.-J., Choi, S., Lee, Y., et al.Capsiate, a nonpungent capsaicin-like compound, inhibits angiogenesis and vascular permeability via a direct inhibition of Src kinase activityCancer Res.68(1)227-235(2008) 2.Iida, Y., Kobata, T.M., Morita, A., et al.TRPV1 activation and induction of nociceptive response by a non-pungent capsaicin-like compound, capsiateNeuropharmacology44(7)958-967(2003) 3.Lee, J.J., Lee, Y.S., Lee, E.-J., et al.Capsiate inhibits DNFB-induced atopic dermatitis in NC/Nga mice through mast cell and CD4+ T-cell inactivationJ. Invest. Dermatol.135(8)1977-1985(2015) 4.Haramizu, S., Kawabata, F., Ohnuki, K., et al.Capsiate, a non-pungent capsaicin analog, reduces body fat without weight rebound like swimming exercise in miceBiomed. Res.32(4)279-284(2011)
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原創作者：上海莼試生物技術有限公司
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普票匯款信息
賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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