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DB07268

  • 產品貨號:CS-01Y69491
  • 產品價格:電議
  • 產品產地:進口、國產
  • 包裝類型:10mM (in 1mL DMSO) 5mg 10mg 50mg 100mg
  • 采購熱度:255
  • 庫存:100
  • CAS號:929007-72-7
  • 方法:
  • 含量:>98.00%
  • 品牌名稱:莼試
  • 分子式:C17H15N5O2
  • 分子量:321.33

簡介內容:質量保證、價格優惠

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化學性質:                                                                                                             

規格

10mM (in 1mL DMSO) 5mg 10mg 50mg 100mg

CAS

 929007-72-7

別名

DB 07268;DB-07268

化學名

2-[[2-(3-hydroxyanilino)pyrimidin-4-yl]amino]benzamide

分子式

C17H15N5O2

分子量

321.33

溶解度

15.2 mg/mL in DMSO

儲存條件

Store at -20°C

General tips

For obtaining a higher solubility , please warm the tube at 37 and shake it in the ultrasonic bath for a while.

Shipping Condition

Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

 

產品描述:                                                                                                            

IC50: 9 nM for JNK1

DB07268 is a JNK1 inhibitor. The c-Jun N-terminal kinases (JNKs) are members of the mitogen-activated protein kinase family. Three JNK isoforms (JNK1, 2 and 3) have been identified. There is growing evidences indicating that activation of the JNK activity is involved in a number of human disease settings. Therefore, considerable efforts have been directed toward the identification of JNK inhibitors suitable for clinical development.

In vitro: The selectivity data of DB07268 against a panel of kinases has been tested. Results showed that DB07268 had some degree of selectivity over quite a few kinases with the exceptions of PLK, CHK1, and CK2. Although d DB07268 showed submicromolar potency against these three kinases, it still appeared to exhibit at least 70- to 90-fold greater potency against JNK1 than PLK, CHK1, and CK2 [1].

In vivo: Several analogs of DB07268 were profiled in vivo. These compounds had a range of exposure in rats and mice. Some had excellent brain penetration despite having poor rat pharmacokinetics, while others had a more balanced profile. Unfortunately, the most potent analog exhibited poor rat pk demonstrated by a short half-life, low oral absorption and poor brain penetration. One DB07268 analog likely exhibited modest rat pk with low clearance and decent oral absorption. This analog also showed modest brain penetration [1].

Clinical trial: So far, no clinical study has been reported.

特別提醒:                                                                                                              

1. 本產品僅供科研使用。請勿用于醫藥、臨床診斷或治療,食品及化妝品等用途。請勿存放于普通住宅區。

2. 為了您的安全和健康,請穿好實驗服并佩戴一次性手套和口罩操作。

原創作者:上海莼試生物技術有限公司

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