13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
在線訂購 免費訂購熱線：021-59541103 021-60443211
標簽:Orlistat-d3
聯系人:高小姐
電話:021-59541103 021-60443211
手機:13585831301
Q Q： 3004967995
Email:3004967995@qq.com
詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 1 mg |
| CAS | 1356930-46-5 |
| 別名 | N/A |
| 化學名 | N/A |
| 分子式 | C29H50D3NO5 |
| 分子量 | 498.8 |
| 溶解度 | Chloroform: slightly soluble,Methanol: slightly soluble |
| 儲存條件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor.1,2,3 It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 μM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 μg/ml, respectively) but does not inhibit fatty acid amide hydrolase (FAAH) or KIAA1363 (IC50s = >100 μM for both). Orlistat decreases ionomycin-induced production of the endocannabinoid 2-arachidonoyl glycerol (2-AG) in N18TG2 murine neuroblastoma cells when used at a concentration of 1 μM.4 It also inhibits fatty acid synthase (FASN; Kiapp = ~0.1 μM for the human enzyme) and the proliferation of PC3 prostate cancer cells in a concentration-dependent manner.5 Orlistat (10 mg/kg) decreases serum cholesterol levels and total body weight in a mouse model of obesity induced by a high-fat diet.6 Formulations containing orlistat have been used in the treatment of adult obesity.
1.Bisogno, T., Howell, F., Williams, G., et al.Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brainJ. Cell Biol.163(3)463-468(2003) 2.Hoover, H.S., Blankman, J.L., Niessen, S., et al.Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profilingBioorg. Med. Chem. Lett.18(22)5838-5841(2008) 3.Bustanji, Y., Issa, A., Mohammad, M., et al.Inhibition of hormone sensitive lipase and pancreatic lipase by Rosmarinus officinalis extract and selected phenolic constituentsJ. Med. Plant Res.4(21)2235-2242(2010) 4.Bisogno, T., Cascio, M.G., Saha, B., et al.Development of the first potent and specific inhibitors of endocannabinoid biosynthesisBiochim. Biophys. Acta1761(2)205-212(2006) 5.Kridel, S.J., Axelrod, F., Rozenkrantz, N., et al.Orlistat is a novel inhibitor of fatty acid synthase with antitumor activityCancer Res.64(6)2070-2075(2004) 6.Ji, W., Zhao, M., Wang, M., et al.Effects of canagliflozin on weight loss in high-fat diet-induced obese micePLoS One12(6)e0179960(2017)
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1. 本產品僅供科研使用。請勿用于醫藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區。
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原創作者：上海莼試生物技術有限公司
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普票匯款信息
賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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