13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
在線訂購 免費訂購熱線：021-59541103 021-60443211
聯系人:高小姐
電話:021-59541103 021-60443211
手機:13585831301
Q Q： 3004967995
Email:3004967995@qq.com
詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 100mg 250mg 500mg 1g |
| CAS | 62-68-0 |
| 別名 | RP 5171|U 5446 |
| 化學名 | α-phenyl-α-propyl-benzeneacetic acid, 2-(diethylamino)ethyl ester, monohydrochloride |
| 分子式 | C23H31NO2 HCl |
| 分子量 | 390.0 |
| 溶解度 | ≥ 20.2mg/mL in DMSO |
| 儲存條件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
IC50: in the μM range when tested using human liver microsomes
SKF 525A is a cytochrome P (CYP)450 inhibitor.
Cytochromes P450 (CYPs) use various molecules as substrates in enzymatic reactions. CYPs are the metabolic oxidase enzymes in electron transfer chains, categorized as P450-containing systems.
In vitro: Previous study found that when incubated with human liver microsomes, SKF525A could undergo CYP-dependent oxidative N-deethylation to its secondary amine metabolite SKF8742. In addition, SKF525A and its metabolite and primary amine analog all inhibited CYP2B6-, CYP2C9-, CYP2C19-, CYP2D6-, as well as CYP3A-selective reactions to various degrees but had little effect on CYP1A2, CYP2A6, and CYP2E1 reactions [1].
In vivo: Animal study found that SKF 525A at 1.5-9 mg/kg could reduce or abolish the hypertensive effect of McN-A-343, DMPP and nicotine, but could neither noticeably affect the hypertensive effect of tyramine, adrenaline and noradrenaline, nor the hypotensive effect of acetylcholine and orciprenaline. Thus, SKF 525A was able to block the rat sympathetic ganglia and the adrenal medulla and such blockade was non-specific. Moreover, the blockade might result from the stabilizing effect of SKF 525A on postsynaptic membranes of the sympathetic ganglia and the adrenal medulla [2].
Clinical trial: Up to now, SKF 525A is still in the preclinical development stage.
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1. 本產品僅供科研使用。請勿用于醫藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區。
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原創作者：上海莼試生物技術有限公司
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普票匯款信息
賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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