13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
在線訂購 免費訂購熱線：021-59541103 021-60443211
標簽:Muraglitazar
聯系人:高小姐
電話:021-59541103 021-60443211
手機:13585831301
Q Q： 3004967995
Email:3004967995@qq.com
詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 1mg |
| CAS | 331741-94-7 |
| 別名 | BMS-298585 |
| 化學名 | N-[(4-methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]-glycine |
| 分子式 | C29H28N2O7 |
| 分子量 | 516.5 |
| 溶解度 | Chloroform: Slightly Soluble,DMSO: Soluble,Methanol: Slightly Soluble |
| 儲存條件 | Store at 4°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
IC50: 0.42 μM: shows agonistic activity at peroxisome proliferator-activated receptor α (PPARα)
IC50: 0.14 μM: shows agonistic activity at PPARγ.
Muraglitazar, a dual agonist of PPARα and PPARγ, induces an increase in HDL-C levels, a reduction of apolipoprotein B, total cholesterol, HbA1c and triglyceride. Muraglitazar is related to an increased risk of heart failure and adverse cardiovascular events. The PPARs, as a subfamily of the 48-member nuclear-receptor superfamily, regulate gene expression in response to ligand binding and are probably involved in pathogenesis, including insulin resistance, diabetes as well as its related complications. PPARα and PPARγ function in adipocyte maturation, lipid metabolism, and fatty acid storage.
In vitro: In murine J774 macrophages, Muraglitazar dose-dependently reduced lipopolysaccharide-induced inducible nitric oxide synthase (iNOS) expression, nitrous oxide, IL-6 and TNFα production and showed no effect on cell viability at the given concentration. Muraglitazar decreased the levels of iNOS mRNA expression, suggesting that the suppressive effect of muraglitazar was mediated at the level of iNOS transcription. In human HEK293 cells, muraglitazar did not affect the nuclear levels of NF- κB p65 compared to the control and did not modulate NF-κB-mediated transcription [1].
In vivo: Male Charles River mice were administrated orally with muraglitazar at a dose of 12.5, 25, 50 mg/kg for six hours. Muraglitazar, in a dose-dependent fashion, prevented the development of oedema. In addition, muraglitazar dose-dependently attenuated inflammation and decreased the levels of IL-6, TNFα and iNOS mRNA [1].
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1. 本產品僅供科研使用。請勿用于醫藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區。
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原創作者：上海莼試生物技術有限公司
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普票匯款信息
賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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