13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
在線訂購 免費訂購熱線：021-59541103 021-60443211
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詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 1mg 5mg 10mg |
| CAS | 1781835-13-9 |
| 別名 | LSD1 Inhibitor IV |
| 化學名 | RN-1, monohydrochloride |
| 分子式 | C23H29N3O2 ? 2HCl |
| 分子量 | 452.4 |
| 溶解度 | ≤0.3mg/ml in DMSO |
| 儲存條件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
RN-1 (hydrochloride) is a brain-penetrant, potent and irreversible LSD1 inhibitor with IC50 values of 10-70 nM [1].
Lysine-specific demethylase 1 (LSD1) is a flavin-dependent monoamine oxidase that demethylate mono- and di-methylated lysines, specifically histone 3, lysines 4 and 9 (H3K4 and H3K9) [2].
RN-1 (hydrochloride) is a potent and irreversible LSD1 inhibitor with IC50 values of 10-70 nM. However, RN-1 is much less effective against MAO-A and MAO-B with IC50 values of 0.51 and 2.785 μM, respectively [1]. In ovarian cancer lines, RN-1 also induced cytotoxicity, which was correlated with the LSD1 inhibitory potential [3].
Following intraperitoneal administration in mice, RN-1 penetrated the blood-brain barrier and the brain/plasma exposure ratio was 88.9. In mice, RN-1 significantly impaired long-term memory but not short-term memory. And long-term memory impairment was due to a brain-specific effect [1]. In a sickle cell disease (SCD) mouse model, RN-1 induced HbF synthesis and increased frequencies of HbF-positive cells and mature erythrocytes, as well as reduced reticulocytes and sickle cells. And the RN-1 treated mice did not exhibit the necrotic lesions in the liver and spleen [4].
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原創作者：上海莼試生物技術有限公司
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賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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