產(chǎn)品目錄

規(guī)格	500 μg 1 mg 5 mg 10 mg
CAS	342611-14-7
別名	N/A
化學(xué)名	N/A
分子式	C2H3D4NO3S
分子量	129.2
溶解度	PBS (pH 7.2): 10 mg/ml
儲(chǔ)存條件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產(chǎn)品描述：

Taurine-d4 is intended for use as an internal standard for the quantification of taurine by GC- or LC-MS. Taurine is a sulfur-containing amino acid produced endogenously and also ingested in the diet.1 It is ubiquitously present in most cells and has diverse biological activities, including antioxidative, anticancer, cardioprotective, and neuroprotective properties.1,2,3,4 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals when used at concentrations ranging from 125 to 1,000 μg/ml and decreases the viability of MCF-7 and MDA-MB-231 human breast cancer cells.2 It prevents left ventricular dysfunction in the mdx mouse model of late-stage Duchenne muscular dystrophy when administered at a dose of 1 g/kg per day for six months.3 Taurine (100 μM) prevents neurotoxicity induced by amyloid-β (Aβ) or the glutamate receptor agonists glutamate, NMDA , or kainic acid in chick embryonic retinal neurons, an effect that can be blocked by the GABAA receptor antagonist picrotoxin .4

1.Schaffer, S., and Kim, H.W.Effects and mechanisms of taurine as a therapeutic agentBiomol. Ther. (Seoul)26(3)225-241(2018) 2.Choi, E.-J., Tang, Y., Lee, C.B., et al.Investigation of antioxidant and anticancer potential of taurine by means of multiple chemical and biological assaysTaurine 9(2018) 3.Mele, A., Manturano, P., De Bellis, M., et al.A long-term treatment with taurine prevents cardiac dysfunction in mdx miceTransl. Res.20482-99(2019) 4.Louzada, P.R., Lima, A.C.P., Mendon?a-Silva, D.L., et al.Taurine prevents the neurotoxicity of ?-amyloid and glutamate receptor agonists: Activation of GABA receptors and possible implications for Alzheimer’s disease and other neurological disordersFASEB J.18(3)511-518(2004)

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原創(chuàng)作者：上海莼試生物技術(shù)有限公司

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