產品目錄

規格	1mg 5mg 10mg 25mg
CAS	21343-40-8
別名	25-hydroxy Vitamin D2
化學名	(1S,3Z)-3-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-6-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexan-1-ol
分子式	C28H44O2
分子量	412.66
溶解度	DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml
儲存條件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request

產品描述：

Ercalcidiol is a metabolite of vitamin D2 and is a VDR-like receptor [1].

Vitamin D is a group of fat-soluble secosteroids and plays an important role in enhancing intestinal absorption of calcium, iron, magnesium, phosphate and zinc. Ercalcidiol (25-hydroxy Vitamin D2) and 25-hydroxyergocalciferol (aka 25-hydroxyvitamin D2 — abbreviated 25(OH) D2) are vitamin D metabolites and Ercalcidiol is converted to 25-hydroxyergocalciferol in liver. Through measuring the level of Ercalcidiol and 25-hydroxyergocalciferol in serum can detect the person's vitamin D status [2] [3].

Using isolated perfused rat kidney model, it was demonstrated that Ercalcidiol not only converted into 24, 25-dihydroxyvitamin D2 but also converted into two other new metabolites-24, 25, 28-trihydroxyvitamin D2 and 24, 25, 26-trihydroxyvitamin D2 [4]. When tested with male weanling rat model, it was demonstrated that either a protein deficiency or a total food restriction during the early postweaning period had no effect on the synthesis and transport of Ercalcidiol and 23, 25-dihydroxyvitamin D in plama [5].

References:

[1]. Jones, G., H.K. Schnoes, and H.F. DeLuca, An in vitro study of vitamin D2 hydroxylases in the chick. J Biol Chem, 1976. 251(1): p. 24-8.

[2]. Newman, M.S., et al., A liquid chromatography/tandem mass spectrometry method for determination of 25-hydroxy vitamin D2 and 25-hydroxy vitamin D3 in dried blood spots: a potential adjunct to diabetes and cardiometabolic risk screening. J Diabetes Sci Technol, 2009. 3(1): p. 156-62.

[3]. Thacher, T.D., et al., Comparison of metabolism of vitamins D2 and D3 in children with nutritional rickets. J Bone Miner Res, 2010. 25(9): p. 1988-95.

[4]. Reddy GS1, Tserng KY. 24, 25, 28-trihydroxyvitamin D2 and 24, 25, 26-trihydroxyvitamin D2: novel metabolites of vitamin D2.Biochemistry. 1990 Jan 30; 29(4):943-9.

[5]. Philbrick DJ, Hollis BW, Draper HH. Effects of protein deficiency on plasma levels of 25-hydroxyvitamin and 24, 25-dihydroxyvitamin D in the rat.

Am J Clin Nutr. 1980 Oct;33(10):2174-6.

特別提醒：

1. 本產品僅供科研使用。請勿用于醫藥、臨床診斷或治療，食品及化妝品等用途。請勿存放于普通住宅區。

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原創作者：上海莼試生物技術有限公司

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