13585831301
021-59541103 021-60443211
3004967995
13585831301021-59541103 021-604432113004967995
在線訂購 免費訂購熱線：021-59541103 021-60443211
聯系人:高小姐
電話:021-59541103 021-60443211
手機:13585831301
Q Q： 3004967995
Email:3004967995@qq.com
詳細地址：上海嘉定區嘉羅公路1661
化學性質：
| 規格 | 10mM*1mLinDMSO 5mg 10mg 25mg 50mg 100mg |
| CAS | 1354707-41-7 |
| 別名 | N/A |
| 化學名 | N/A |
| 分子式 | C18H13F2NO3 |
| 分子量 | 329.3 |
| 溶解度 | DMSO : ≥ 106.66 mg/mL (323.90 mM) |
| 儲存條件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice |
產品描述：
Mitochonic acid 5 binds mitochondria and ameliorates renal tubular and cardiac myocyte damage. Mitochonic acid 5 modulates mitochondrial ATP synthesis.
Mitochonic acid 5 (MA-5) modulates mitochondrial ATP synthesis independently of oxidative phosphorylation and the electron transport chain. Mitochondrial dysfunction causes increased oxidative stress and depletion of ATP, which are involved in the etiology of a variety of renal diseases[1]. Mitochonic acid 5 (MA-5), which is derived from the plant growth hormone indole-3-acetic acid, can protect mitochondrial function by regulating energy metabolism and reducing mitochondrial oxidative stress. To observe the protective role of Mitochonic acid 5 in microglia under inflammatory conditions, TNFα is applied. Subsequently, the MTT assay is used to evaluate cell viability. In response to the TNFα treatment, cell viability significantly decreases. However, this effect is dose-dependently inhibited by Mitochonic acid 5 treatment[2].
Administration of Mitochonic acid 5 (MA-5) to an ischemia-reperfusion injury model and a cisplatin-induced nephropathy model improved renal function. To examine the tissue-protective effect of Mitochonic acid 5, the oral bioavailability is examined. Oral administration of Mitochonic acid 5 increases the plasma concentration in a dose-response manner at the peak time of 1 hour[1].
[1]. Suzuki T, et al. Mitochonic Acid 5 Binds Mitochondria and Ameliorates Renal Tubular and Cardiac Myocyte Damage. J Am Soc Nephrol. 2016 Jul;27(7):1925-32. [2]. Lei Q, et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018 Apr 5;23:14.
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原創作者：上海莼試生物技術有限公司
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賬 戶 名：上海生物
開 戶 行：中國銀行山東省分行營業部
賬 號：2169 2341 6278
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